학술논문
Lithium이 家兔腦에 미치는 影響에 關한 病理組織學的 硏究
이용수 0
- 영문명
- EFFECT OF LITHIUM CARBONATE ON BRAIN OF RABBITS A HISTOPATHOLOGICAL STUDY
- 발행기관
- 대한신경정신의학회
- 저자명
- 吳承換
- 간행물 정보
- 『신경정신의학』제15권 제1호, 28~44쪽, 전체 17쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 1976.01.30
4,840원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
It was well known that the Lithium intoxication as a complication of the use of Lithium Carbonate
as a drug regiment for mental science field, but the cerebral morphology concerning to it s intoxication
was yet unknown.
A study on experimental encephalopathy in rabbits induced by repeated administration of Lithium
Carbonate was made as an attempt to produce toxic inflammatory losions of brain as morphological
view point, concerning to a certain neurologic disorders. The results and conclusions obtained
were follows:
1) In the animal groups in which were administered Lithium Carbonate 10mg, 30mg or 50mg/kg/
day repeatedly, per oral route, the histopathologic changes were non-spocific, such as reactive, reversible
nouronal changes and mild to moderate circulatory disturbances, observed in all cases.
2) In the animal group in which was administered Lithium Carbonate 10mg/kg/day plus Chlorpromazine
10mg/kg/day combination, repeatedly, per oral route, the histopathologic changes were similar
as above groups, in all cases.
3) The encephalitic findings were distinct in the group in which was administered Lithium Carbonate
lOOmg/kg/day, repeatedly, per oral route.
The histopathologic changes were considerably severe and irreversible neuronal changes, such as
chromatolyais, neurenophagy and focal gliosis, as well as perivascular round cell cuffings, patchy
hemorrhages and focal demyelinization.
4) As results, Lithium induced-encephalophathy in rabbits could be achieved by means of producing
cytotoxic cerebral condition through the repeated administration of Lithium carbonate lOOmg or more
/kg/day per oral route, which could be attributed to fataldose in the animal group.
목차
緒 論
實驗材料 및 方法
實驗成辕
考 按
結 論
參考文獻
英文抄錄
寫眞附圃
키워드
해당간행물 수록 논문
참고문헌
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!