비만 유전자 단일 염기 다형성 문헌 고찰

• 영문명: A literature Review of Single Nucleotide Polymorphisms in Obesity Genes
• 발행기관: 한방비만학회
• 저자명: 송희옥(Hee Ok Song) 김성수(Sung Soo Kim)
• 간행물 정보: 『대한한방비만학회지』제4권 1호, 139~160쪽, 전체 22쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2004.12.31

영문 초록

The obesity is detrimental to the health of people living in affluent societies. Individual differences in energy metabolism are caused primarily by single nucleotide polymorphisms(SNPs), some of which promote the development of obesity-related type 2 diabetes mellitus. Type 2 diabetes mellitus is a common multifactorial genetic syndrome, which is determined by several different genes and environmental factors. In this review, five major conclusions are reached: (1)To be clinically significant, SNPs must be relevant, prevalent, modifiable, and measurable. (2)Differences in SNPs may have been caused by famine, ultraviolet light, alcohol, climate, agricultural revolution, livestock, lactase persistence, and westernized lifestyle. (3)Candidate obesity genes of calorie intake restriction are SIM 1, MC3R, MC4R, AGRP, CART, CCK, CNTFR, DRD2, Ghrelin, 5-HT receptor, NPY, PON and those of energy metabolism are LEP, LEPR, UCP1, UCP2, UCP3, B2AR, B3AR, PGC-1, Androgen receptor and those of fat mobilization are AGT, ACE, ADA, APM1, Apolipoproteins, PPAR, FABP, FOXC2, GCGR, 11-βHSDI, LDLR, Hormonal sensitive lipase, Perilipin, TNF-α ,TNF-β. (4)Candidate obesity genes in the eastern are NPY, LEP, LEPR, UCP1, UCP2, UCP3, B2AR, B3AR, ACE, APM1, PPAR, and FABP. (5)Candidate obesity genes in type 2 diabetes mellitus are MC3R, MC4R, B2AR, B3AR, ADA, APM1, PPAR, FABP, FOXC2, PC1, PC2, ABCC8, CAPN10, CYP19, CYP7, ENPP1, GCK, GYS1, IGF, IL-6, Insulin receptor, IRS, and LPL. The discovery of SNPs will lead to a greater understanding of the pathogenesis of obesity and to better diagnostics, treatment, and eventually prevention.

목차

Ⅰ. 서 론

Ⅱ. 본 론

Ⅲ. 고 찰

Ⅳ. 결 론

참고문헌

키워드

obesity single nucleotide polymorphisms type 2 diabetes mellitus