Peroxisome Proliferator-Activated Receptor-γ 2 (PPARγ2) Pro12Ala (P12A) 유전자 다형성이 한국여성의 체지방분포에 미치는 영향

• 영문명: Effects of Peroxisome Proliferator-Activated Receptor-gamma Pro12Ala Polymorphism on Body Fat Distribution in Female Korean Subjects
• 발행기관: 한방비만학회
• 저자명: 김길수(Kil Soo Kim) 최선미(Sun Mi Choi) 신승우(Seung Uoo Shin) 양현성(Hyun Sung Yang) 윤유식(Yoo Sik Yoon)
• 간행물 정보: 『대한한방비만학회지』제4권 1호, 1~12쪽, 전체 12쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2004.12.31

영문 초록

Objectives : The effects of peroxisome proliferator-activated receptor γ2 (PPARγ2) Pro12Ala (P12A) polymorphism on body mass index (BMI) and type 2 diabetes are well documented; however, until now, only a few studies have evaluated the effects of this polymorphism on body fat distribution. This study was conducted to elucidate the effects of this polymorphism on computed tomography (CT)-measured body fat distribution and other obesity-related parameters in Korean female subjects. Methods & Results : The frequencies of PPARγ2 genotypes were: PP type, 93.0%; PA type, 6.8%; and AA type, 0.2%. The frequency of the A allele was 0.035. Body weight (P .012), BMI (P .012), and waist-to-hip ratio (WHR) (P .001) were significantly higher in subjects with PA/AA compared with subjects with PP. When body composition was analyzed by bioimpedance analysis, lean body mass and body water content were similar between the 2 groups. However, body fat mass (P .003) and body fat percent (P .025) were significantly higher in subjects with PA/AA compared with subjects with PP. Among overweight subjects with BMI of greater than 25, PA/AA was associated with significantly higher abdominal subcutaneous fat (P .000), abdominal visceral fat (P .031), and subcutaneous upper and lower thigh adipose tissue (P .010 and .013). However, among lean subjects with BMI of less than 25, no significant differences associated with PPARγ2 genotype were found, suggesting that the fat-accumulating effects of the PA/AA genotype were evident only among overweight subjects, but not among lean subjects. When serum lipid profiles, glucose, and liver function indicators were compared among overweight subjects, no significant difference associated with PPARγ2 genotype was found. Changes in body weight, BMI, WHR, and body fat mass were measured among overweight subjects who finished a 1-month weight lose program of a hypocaloric diet and exercise; no significant differences associated with PPARγ2 genotype were found. Conclusions : The results of this study suggest that the PPARγ2 PA/AA genotype is associated with increased subcutaneous and visceral fat areas in overweight Korean female subjects, but does not significantly affect serum biochemical parameters and outcomes of weight loss programs.1)

목차

Ⅰ. 서 론

Ⅱ. 연구대상 및 방법

Ⅲ. 결 과

Ⅳ. 고 찰

참고문헌

키워드

Peroxisome proliferator-activated receptor γ2 PPARγ2 Polymorphism Body fat distribution