학술논문
D. D. S. 중독으로 인한 정신증
이용수 2
- 영문명
- TOXIC PSYCHOSIS ASSOCIATED WITH D. D. S.
- 발행기관
- 대한신경정신의학회
- 저자명
- 김학성
- 간행물 정보
- 『신경정신의학』제16권 제2호, 234~240쪽, 전체 7쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 1977.05.30
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국문 초록
영문 초록
Several reports suggested that DDS could induce psychosis, whereas it seems that there are no clear
descriptions about dosage, clinical course, symptomatology and prognosis. The author reported three
cases of toxic psychosis in Mn-3eprciis persons follcwirg irassive adminstraticn cf DDS giving
eirphasis to clinical characteristics.
The first case, a SO year old irale, presented definite psychotic symptoms with paranoid picture
after daily administration of 300mg of DDS for 40 days. The second case, a 13 year old male, had
mental symptoms similar to those of the first case 2 days after the administration of 1,2CCnig cf DDS
in 3 days. In both cases, sucK symptcirs es slowly increasing irritability, anorexia and insomnia were
presented prior to the development of definite psychosis.
The last case, a 21 year old female, took more than 1,000mg of DDS at once. Several hours
after ingestion, acute intoxication symptoms such as nausea, vomiting, cyanosis and loss of consciousness
appeared. Ten days later, she improved in her mental state except fatigability and visual
disturbance. But after 30 days of lucid period, psychotic symptoms with hysterical picture were
manifested.
In all cases, there was no neurological abnormality except typical organic brain syndrome such
as disorientation, distractability, disturbance of calculation and recent memory, and exacerbating
tendency at night.
Antipsychotics were used for the treatment of psychotic symptoms, which were gradually allevi-
ated after at least 2 months of treatment.
The following facts could be extracted from the clinical experiences with these patients.
1) Psychotic symptoms were presented by both single and repeated administration of DDS.
2) Acute brain syndrome was observed in all cases, whereas it’s mental symptom clearly reflected
premorbid personalily of the patients.
3) There was a lucid period before the onset of psychotic symptom in the case of acute intoxication
by single dose. In this case, visual disturbance with retinal hemorrage and macular degeneration
was noticed.
4) Methemoglobinemia was not found in all cases, suggesting that psychotic manifestation might not
be related to cellular hypoxia due to the methemoglobinemia but to the serum concentration and
toxicity of the sulfone per se.
5) Recovery seemed to be the rule but required prolonged treatment
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