백출, 어성초, 금은화, 황금, 황련과 Metformin의 병용 투여 시 항산화 효과 및 전지방세포 분화 억제 효과

• 영문명: Original Article : Effect of Atractylodes Rhizoma Alba, Houttuyniae Herba, Lonicerae Flos, Agrobacterium Rhizogenes and Coptidis Rhizoma Extracts Combined with Metformin on the Antioxidant and Adipocyte Differentiate Inhibition
• 발행기관: 한방비만학회
• 저자명: 장세주(Se ju Chang) 한경선(Kyung sun Han) 왕경화(Jing Hua Wang) 채희성(Hee Sung Chae) 최영희(Yong Hee Choi) 진영원(You
• 간행물 정보: 『대한한방비만학회지』제15권 1호, 24~32쪽, 전체 9쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2015.06.30

영문 초록

Objectives: This study was to investigate the antioxiative capacity, antiobesity effects of Atractylodes Rhizoma Alba, Houttuyniae Herba, Lonicerae Flos, Agrobacterium Rhizogenes, and Coptidis Rhizoma on Raw 264.7 and 3T3-L1 cell lines. Methods: Three different types of herb extracts (A. Rhizoma Alba, H. Herba, L. Flos, A. Rhizogenes, and C. Rhizoma; water 100%, ethanol 30%, ethanol 100%) were used in this study. Total polyphenol compound, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, reactive oxygen species (ROS) activity, NO production and cell proliferation were measured. Results: Total polyphenol compound measurement of L. Flos, A. Rhizogenes, and C. Rhizoma extracts were higher than A. Rhizoma Alba, H. Herba. DPPH radical scavenging activity, ROS activity and NO production of A. Rhizogenes, C. Rhizoma extracts were lower than L. Flos, A. Rhizoma, and H. Herba. Conclusions: Metformin and A. Rhizogenes, C. Rhizoma, A. Rhizoma Alba, and L. Flos extracts combination groups showed synergistic effect on adipocyte differentiation inhibition and antioxidative activity.

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키워드

Metformin Herbal medicine Combination Antioxidative Adipocyte differentiation