고지방식이 비만마우스 모델에서 파키스탄산 및 중국산 마황으로 조성된 강지환(降脂丸)-1, 2, 3, 4와 강지환(降脂丸)-1합가미소체환(合加味消滯丸)의 체중감량효과 비교

• 영문명: Original Article : Comparison of Gangji-hwan-1, 2, 3, 4 and Combination of Gangji-hwan-1 and Gamisoche-hwan in the Reducing Effects of Body Weight in a High Fat Diet-Fed Obese Mice
• 발행기관: 한방비만학회
• 저자명: 유재상(Jae Sang Yoo) 구자룡(Ja Ryong Ku) 윤기현(Ki Hyeon Yoon) 조주흠(Ju Heum Jo) 장두현(Du Hyon Jang) 정양삼(Yang Sam
• 간행물 정보: 『대한한방비만학회지』제15권 1호, 9~23쪽, 전체 15쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2015.06.30

영문 초록

Objectives: This study was investigated the improvement effects of Pakistani Ephedra herba- containing Gangji-hwan-1, 2, 3 (Di-fatty; DF-1, 2, 3), Chinese Ephedra herba-containing Gangji- hwan-4 (DF-4) and combination of DF-1 and Gamisoche-hwan (GSH) on obesity in a high fat diet-fed obese mouse model.Methods: Eight-week-old C57BL/6N mice were divided into seven groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-1, 2, 3, 4, and DF-1+GSH groups given a high fat diet with DF-1, 2, 3, 4 (40, 80, 160, 80 mg/kg), and DF-1+ GSH (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio (FER), blood lipid markers, liver histology, and fat weight and histology were examined. Results: Body weight gain was significantly decreased in DF and DF-1+GSH groups compared with control. The extent of decreases was eminent in DF-1+GSH group. FER and circulating concentration of leptin were decreased in DF and DF-1+GSH groups compared with control. Circulating concentrations of triglyceride, glucose and insulin were decreased in DF and DF-1+GSH groups compared with control. The size of adipocytes were decreased by DF and DF-1+GSH groups compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF and DF-1+GSH groups decreased the number of large adipocytes. Conclusions: In conclusion, these results suggest that DF and DF-1+GSH groups decrease FER, plasma leptin concentration, blood anti-obesity biomarkers and fat mass, improves body weight gain. In addition, these effects were more effective in DF-1+GSH combination group than in DF-1, 2, 3, 4 groups.

목차

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대상 및 방법

결 과

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감사의 글

References

키워드

Gangji hwan Gamisoche hwan Pakistani Ephedra Herba Chinese Ephedra Herba Obesity Leptin