Clorazepate 및 Medazepam이 가토 혈중 주정 농도에 미치는 영향에 관한 실험적 연구

• 영문명: EFFECTS OF CLORAZEPATE AND MEDAZEPAM ON BLOOD ALCOHOL LEVEL IN RABBITS
• 발행기관: 대한신경정신의학회
• 저자명: 신정호
• 간행물 정보: 『신경정신의학』제19권 제2호, 55~62쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1980.05.31

영문 초록

Both clorazepate and medazepam are relatively newer anxiolytics of benzodiazepine derivativesr clorazepate is carboxylated form cf desmethyldiazepam, and medazepam is benzodiazepine analogue of a 2-ketone omitted. These drugs show characteristic taming effect, muscle relaxant, and anticonvulsant properties with relatively little side effect and these drugs indicate rapid absorption and rapid biotransform ation by oral administration, with more rapid onset of action for the former. It is found that desmethyldiazepam is the major metabolite of clorazepate and medazepam, which is regarded to be important active substance to produce beneficial effects of these benzodiazepine derivatives in clinical application Investigators suggested that any new psychotropic drugs should be tested for its interaction with alcohol, because they might precipitate the risk situation in case of consuming them concurrently. Recently it has been reported that various psychotropic agents tended to elevate the blood alcohol level. In view of these reports, the author conducted an animal experiment to investigate the effect of both clorazepate and medazepam on the blood alcohol level in rabbits

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실험 재료 및 실험 방법

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