血發 Chlorpromazine濃度와 그 臨床的 意義

• 영문명: Plasma Chlorpromazine Level and Clinical Significance
• 발행기관: 대한신경정신의학회
• 저자명: 崔宗烧 李定均 徐維憲 朴賛 雄
• 간행물 정보: 『신경정신의학』제20권 제1호, 27~35쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1981.02.28

영문 초록

Plasma chlorpromazine level and some aspects of the clinical significance were studied with 20 schizophrenics. The results were as follows; The (so-called) steady state of plasma chlorpromazine level was arrived at about 12th day of the drug administration in a dose of 300mg/day on a fixed maintenane regimen. Thereafter the level tended to decline slightly. After arriving at the steady state, a significant positive correlation was observed between the plasma level and the dose of the drug, both in intra-and interpatient comparisons ( r = +0.5855, p<0.025). On a fixed chlorpromazine dosage, the plasma levels showed marked interpatient differences both before and after the initial day of the steady state, though the defferences were more marked before the period of steady state. 579-584 No significant positive correlation could be identified between the plasma level and the drug side reaction, though 78% of the observed side reactions were positively related with the plasma level of 1.5 mcg/ml or above. And again, significant positive correlation was not observed between the plasma level and the clinical improvement. So-called ‘therapeutic window was considerably wide ranging between 0.5 to 2.45 mcg/ml of the plasma level.

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