항정신병약물로 야기된 장시 정좌불능증의 Propranolol 치료효과에 관한 예비적 연구

• 영문명: A Preliminary Study on the Propranolol Effect in the Treatment of Neuroleptic -induced Akathisia
• 발행기관: 대한신경정신의학회
• 저자명: 안재희 장동원 최회정
• 간행물 정보: 『신경정신의학』제25권 제4호, 559~564쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1986.11.30

영문 초록

The purpose of this study was to test the efficacy of propranolol in managing neuroleptic-induced akathisia. Physically healthy hospitalized patients (47 schizophrenic patients and 2 bipolar patients) from the inpatient services of the seoul National Mental Hospital who were being treated with neuroleptics and in whom neuroleptic-induced akathisia developed during the course of therapy were included in the study. The patients were subdivided into two groups and the study was executed double blind, parallel group design comparison of propranolol and benztropine administered for a 7-day period each. The efficacy of two drugs was assessed on 1,3,5,7 day by Extrapyramidal Rating Scale of Chouinard. Response by propranolol was quite rapid, occuring within 24 hours in the significant cases (14/24). D o s e s r e q u ir e d fo r im p r o v e m e n t w e re low(30-90mg/day) and side effects were fewer than benztropine group. According to the statistical analyses, no differential effects were found: both drugs were equally effective and rapid.

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