Evidence-based clinical recommendations for hypofractionated radiotherapy: exploring efficacy and safety - Part 2. Lung (non-small cell lung cancer)

• 영문명: Evidence-based clinical recommendations for hypofractionated radiotherapy: exploring efficacy and safety - Part 2. Lung (non-small cell lung cancer)
• 발행기관: 대한방사선종양학회
• 저자명: Yoo-Kang Kwak Kyung Su Kim Gyu Sang Yoo Hwa Kyung Byun Yeon Joo Kim Yeon-Sil Kim Soo-Yoon Sung Jin Ho Song Byoung Hyuck Kim
• 간행물 정보: 『대한방사선종양학회지』제42권 제2호, 104~115쪽, 전체 12쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2024.06.30

국문 초록

Several recent studies have investigated the use of hypofractionated radiotherapy (HFRT) for various cancers. However, HFRT for non-small cell lung cancer (NSCLC) with or without concurrent chemotherapy is not yet widely used because of concerns about serious side effects and the lack of evidence for improved treatment results. Investigations of HFRT with concurrent chemotherapy in NSCLC have usually been performed in single-arm studies and with a small number of patients, so there are not yet sufficient data. Therefore, the Korean Society for Radiation Oncology Practice Guidelines Committee planned this review article to summarize the evidence on HFRT so far and provide it to radiation oncology clinicians. In summary, HFRT has demonstrated promising results, and the reviewed data support its feasibility and comparable efficacy for the treatment of locally advanced NSCLC. The incidence and severity of esophageal toxicity have been identified as major concerns, particularly when treating large fraction sizes. Strategies, such as esophagus-sparing techniques, image guidance, and dose constraints, may help mitigate this problem and improve treatment tolerability. Continued research and clinical trials are essential to refine treatment strategies, identify optimal patient selection criteria, and enhance therapeutic outcomes.

목차

Introduction

Key Question 1: What Hypofractionation Regimen Could Be Used for LA-NSCLC Treated with Definitive CCRT?

Key Question 2: What Hypofractionation Regimen Could Be Used for LA-NSCLC Treated with Definitive RT Alone without Chemotherapy?

Conclusion

Statement of Ethics

Conflict of Interest

Funding

Author Contributions

Data Availability Statement

References

키워드

Radiation dose hypofractionation Carcinoma Non-small-cell lung