The effects of high-dose radiation therapy on bone: a scoping review

• 영문명: The effects of high-dose radiation therapy on bone: a scoping review
• 발행기관: 대한방사선종양학회
• 저자명: Lawrence Berk
• 간행물 정보: 『대한방사선종양학회지』제42권 제2호, 95~103쪽, 전체 9쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2024.06.30

국문 초록

Purpose This scoping review presents the preclinical and clinical data on the effects of high-dose radiation therapy (RT) on bone structure and function. Materials and Method An extensive PubMed search was performed for the relevant questions. The data were then synthesized into a comprehensive summary of the available relevant in-vitro, preclinical and clinical literature. Results In-vitro studies of high-dose RT on cell cultures show considerable damage in the viability and functional capacity of the primary cells of the bones; the osteoclasts, the osteoblasts, and the osteocytes. In-vivo animal models show that high-dose RT induces significant morphological changes to the bone, inhibits the ability of bone to repair damage, and increases the fragility of the bone. Clinical data show that there is an increasing risk over time of damage to the bone, such as fractures, after high-dose RT. Conclusion These findings suggest that there may be a limit to the safe dose for single-fraction RT, and the long-term consequences of high-dose RT for the patients must be considered.

목차

Introduction

Methods and Materials

Results

Discussion and Conclusion

Statement of Ethics

Conflict of Interest

Funding

Author Contributions

Data Availability Statement

References

키워드

Radiotherapy Radiosurgery Bone and bones Bone fractures Radiation effects Cancer survivors