핵의학 영상에서 계수기반 체적변화 추적에 관한 고찰

• 영문명: A Study on the Tracking of Count-Based Volumetric Changes in Nuclear Medicine Imaging
• 발행기관: 대한핵의학기술학회
• 저자명: 김지현(Ji-Hyeon Kim) 이주영(Jooyoung Lee) 박훈희(Hoon-Hee Park)
• 간행물 정보: 『핵의학기술』Vol.28 No.1, 57~69쪽, 전체 13쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2024.05.30

영문 초록

Purpose: Quantitative analysis through count measurement in nuclear medicine planar images is limited by analysis techniques that are useful for obtaining various clinical information or by organ overlap or artifacts in actual clinical practice. On the other hand, the use of SPECT tomography images is quantitative analysis using volume rather than planar, which is not only free from problems such as projection overlap, but also has excellent quantitative accuracy. In the use of developing SPECT quantitative analysis technology, this study aims to compare the accuracy of quantitative analysis between ROI of the conventional planar images and VOI of the SPECT tomographic images in evaluating the count change happened by the volume change of the source. Materials and Methods: A 99mTcO4 - source(200.17 MBq) was filled with sterilized water in the syringe to create a phantom with an inner diameter volume of 60 cc, and a planar image and a SPECT image were obtained by reducing the volume by 15 cc (25%) respectively. ROI and VOI(threshold: 1~45%, 5% interval) were set for each image obtained to estimate true count and measure the total count, and compared with the preseted volumetric change rate(%). Results: When volume changes of 25%, 50%, and 75% occurred in the initial volume of 60 cc(100%) of the phantom, the average count changes of the measured planar image were 26.8%, 53.2%, 77.5%, and the average count changes of the SPECT image were 24.4%, 50.9%, and 76.8%. In this case, the VOI size(cm3) set showed an average change rate of 25.4%, 51.1%, and 76.6%. The highest threshold value for the accuracy of radioactive concentration by VOI size (average error -1.03%) was 35%, and the VOI size of the same threshold had an error of -17.1% on average compared to the actual volume. Conclusion: On average, the count-based volumetric change rate in nuclear medicine images was able to track changes more accurately using VOI than ROI, but there was no significant difference with relatively similar value. However, the accuracy of radioactive concentration according to individual VOI sizes did not match, but it is considered that a relatively accurate quantitative analysis can be expected when the size of VOI is set smaller than the actual volume.

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대상 및 방법

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키워드

Radioactivity Count VOI ROI