Atlanto-occipital assimilation: embryological basis and its clinical significance

• 영문명: Atlanto-occipital assimilation: embryological basis and its clinical significance
• 발행기관: 대한해부학회
• 저자명: Hari Hara Hanusun N Akanksha Singh Pooja Poddar Jessy J P Neerja Rani Hitesh Gurjar Seema Singh
• 간행물 정보: 『Anatomy and Cell Biology』Vol.57(1), 147~151쪽, 전체 5쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2024.03.30

영문 초록

Atlanto-occipital assimilation is an osseous embryological anomaly of the craniovertebral junction in which the atlas (C1) is fused to the occiput of skull. Embryologically, this assimilation may happen due to failure of the segmentation and separation of the caudal occipital and the cranial cervical sclerotome. The segmentation clock is maintained by NOTCH and WNT signalling pathways along with Hox genes and retinoic acid. This condition is likely to be a consequence of mutation in above mentioned genes. The knowledge of this assimilation may be crucial for the clinicians as it may lead to various neurovascular symptoms. The present case report involves the analysis of atlanto-occipital assimilation with its clinical significance and embryological basis.

목차

Introduction

Case Report

Discussion

ORCID

Author Contributions

Conflicts of Interest

Funding

References

키워드

Assimilation Segmentation clock Signalling pathways Homeotic transformation