꿀벌 독의 독성 강도와 동물에 미치는 영향

• 영문명: Toxicity and Metabolic Effects of Bee Venom in Animals
• 발행기관: 한국동물보건학회
• 저자명: 김하영(Hayoung Kim) 김희연(Hee-Yeon Kim) 김혜주(Hyeju Kim) 이규빈(Kyubin Lee) 안민지(Minji An) 정소연(Soyeon Jeong) 이용호(Yong-Ho Lee)
• 간행물 정보: 『한국동물보건학회지』2권 4호, 213~224쪽, 전체 12쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

Sting injury by bees or wasps have become frequent recently and have become a matter to prevent and consider in companion animal health care. Therefore, it is necessary to better understand the level of toxicity of Hymenoptera insect venom, and in this study, we were to investigate the toxicity of honey bee venom and its effects on animals through an acute toxicity test using mice. The mouse acute toxicity test was performed by intraperitoneally administering 0, 2.5, 5, and 7.5 mg/kg of bee venom to C57BL/6 mice. Body weight changes and blood glucose levels were measured before and after administration. During the administration, major common symptoms were observed. Lethal dose 50(LD50)values were calculated and blood samples were collected from sacrificed animals and used for hematologic examination to measure blood levels of ALB, ALT, AST, BUN, LDL, HDL, and total cholesterol. As a result of the mouse acute toxicity test, the LD50 value was found to be 4.48 mg/kg in male and 5.86 mg/kg in female C57BL/6 mice. Information on the toxicity of bee venom and hematological analysis results will provide basic data for the health care and emergency treatment of animals stung by bees.

목차

1. 서론

2. 재료 및 방법

3. 결과

4. 고찰

5. 결론

ORCID

REFERENCES

키워드

Bee venom C57BL/6 LD50 Hematological analysis Toxicity