학술논문
Differential microbiota network according to colorectal cancer lymph node metastasis stages
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- 영문명
- Differential microbiota network according to colorectal cancer lymph node metastasis stages
- 발행기관
- 대한의학유전학회
- 저자명
- Yeuni Yu Donghyun Han Hyomin Kim Yun Hak Kim Dongjun Lee
- 간행물 정보
- 『대한의학유전학회지』제20권 제2호, 52~59쪽, 전체 8쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2023.12.31
4,000원
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국문 초록
영문 초록
Purpose: Colorectal cancer (CRC) is a common malignancy worldwide and the second leading cause of cancer-related deaths. In addition, lymph node metastasis in CRC is considered an important prognostic factor for predicting disease recurrence and patient survival. Recent studies demonstrated that the microbiome makes substantial contributions to tumor progression, however, there is still unknown about the microbiome associated with lymph node metastasis of CRC. Here, we first reported the microbial and tumor-infiltrating immune cell differences in CRC according to the lymph node metastasis status.
Materials and Methods: Using Next Generation Sequencing data acquired from 368 individuals diagnosed with CRC (N0, 266; N1, 102), we applied the LEfSe to elucidate microbial differences. Subsequent utilization of the Kaplan-Meier survival analysis enabled the identification of particular genera exerting significant influence on patient survival outcomes.
Results: We found 18 genera in the N1 group and 3 genera in the N0 group according to CRC lymph node metastasis stages. In addition, we found that the genera Crenobacter (P=0.046), Maricaulis (P=0.093), and Arsenicicoccus (P=0.035) in the N0 group and Cecembia (P=0.08) and Asanoa (P=0.088) in the N1 group were significantly associated with patient survival according to CRC lymph node metastasis stages. Further, Cecembia is highly correlated to tumor-infiltrating immune cells in lymph node metastasized CRC.
Concolusion: Our study highlights that tumor-infiltrating immune cells and intratumoral microbe diversity are associated with CRC. Also, this potential microbiome-based oncology diagnostic tool warrants further exploration.
목차
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
Funding
Authors' Contributions
References
해당간행물 수록 논문
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- Differential microbiota network according to colorectal cancer lymph node metastasis stages
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- A Korean case of CTCF related neurodevelopmental disorders
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