마취 시행이 치매 발생에 미치는 영향

• 영문명: Influence of Anesthesia on Incidence of Dementias: 8-Year Follow-Up Study
• 발행기관: 대한노인정신의학회
• 저자명: 서수린 형원석 이승훈 김준형 최광연 윤현철 정현강
• 간행물 정보: 『노인정신의학』제27권 제2호, 65~70쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2023.10.31

영문 초록

Objective: Cognitive dysfunction is frequently reported after surgery and anesthesia in elderly patients. This study aims to investigate the incidence of dementia for eight years after anesthesia. Methods: We extracted the data between 2007 and 2020 from the Health Insurance Review and Assessment Service Database. We analyzed risk of developing dementia after anesthesia using Cox proportional hazard models. Results: Data were collected from 62,541 patient. Among them, subjects with and without anesthesia were 15,857 and 46,684, respectively. Subjects with anesthesia had more hypertension, diabetes mellitus and hyperlipemia than those without anesthesia. The risk of dementia incidence was found to increase 1.7 times in subjects with anesthesia (hazard ratio=1.751, 95% confidence interval=1.596-1.921). Even after the correction for gender, age, and comorbidity, the statistical significance of this risk remained (hazard ratio=1.662, 95% confidence interval=1.512-1.827). Conclusion: Our findings suggest that anesthesia possibly contribute on cognitive impairment. Clinician might need closed observation on cognitive function in patients after surgery and anesthesia.

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키워드

마취 치매 수술 인지저하 Anesthesia Dementia Surgery Cognitive decline