Effects of polyphenols of Cocos nuc[fera husk fibre on selected indices of cardiovascular diseases in mice

• 발행기관: 셀메드 세포교정의약학회
• 저자명: Joseph Oluwatope Adebayo Olumuyiwa Sunday Adewumi Simbiat Titilayo Baruwa 외 4명
• 간행물 정보: 『셀메드』Volume 6 Issue 2, 1~7쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2016.05.31

영문 초록

Cocos nucifera (C. nuciferd) oil is indigenously used to treat cardiovascular diseases. However, coconut husk fibre (which is rich in polyphenols) has not been screened for this property. Based on the ethnomedicinal use of polyphenols in treating cardiovascular diseases, this study was carried out to evaluate the effects of polyphenols of C. nucifera husk fibre on selected cardiovascular disease indices in mice. Fifty adult male Swiss albino mice were assigned randomly into five groups (A-E). Mice in groups B, C, D and E were administered 31.25, 62.5, 125, and 250 mg/kg body weight polyphenols of ethyl acetate extract of C. nucifera husk fibre respectively while the control group (A) mice received 5% DMSO for seven days. The mice were sacrificed twenty four hours after the last administration of polyphenols. Heart and plasma lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities and plasma lipid profile were /* determined. Results revealed significant reduction ( p < 0.05) in plasma levels of total cholesterol and * LDL-cholesterol with no significant change ( p > 0.05) in HDL-cholesterol, triglyceride and VLDL levels in the plasma at all doses of polyphenols administered compared to controls. There was significant * reduction ( p < 0.05) in the activities of heart AST and LDH while plasma ALT, AST, and ALP activities * were not significantly altered (p > 0.05) at all doses of polyphenols administered compared to controls. These results suggest that the polyphenols of C. nucifera husk fibre possess cardio-protective properties and also indicate their possible use in the treatment of cardiovascular diseases.

키워드

coconut polyphenols cardiovascular diseases husk fibre