Anti-fatigue effect of fermented porcine placenta through the regulation of fatigue-associated inflammatory cytokines

• 발행기관: 셀메드 세포교정의약학회
• 저자명: Sun-Young Nam Ji-Hyun Go Mikyung Lee Jongbae Kim Hyein Jeong Won Kyung Lee
• 간행물 정보: 『셀메드』Volume 6 Issue 2, 1~7쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2016.05.31

영문 초록

Fatigue is a common complaint and affects the quality of life in modern people. Physical stress may induce activation of certain immune cells. Fermented porcine placenta (FPP) has been used to alleviate fatigue. Inflammatory cytokines are produced by physical stress and results in symptoms of fatigue. However, the role of FPP on fatigue-associated inflammatory cytokine production has not been elucidated yet. Thus, we estimated the anti-fatigue effect of FPP and its active components, leucine (Leu) and lysine (Lys) in activated RAW264.7 macrophages and forced swimming test (FST) fatigue animal model. Pretreatment with FPP, Leu, or Lys significantly inhibited the lipopolysaccharide (LPS)-induced tumor necrosis factor-a, interleukin (IL)-邛，and IL-6 production without inducing cytotoxicity on LPS- stimulated RAW264.7 macrophages. FPP, Leu, or Lys inhibited the production of nitric oxide and downregulated the expression of inducible nitric oxide synthase on LPS-stimulated RAW264.7 macrophages. Furthermore, caspase-1 activities increased by LPS were significantly reduced by FPP, Leu, or Lys. In the FST, inflammatory cytokine levels of the mice administrated with FPP, Lys, and Leu were significantly reduced compared with the control group at 21 days. Collectively, these results show that anti-fatigue effect of FPP and its active components, Leu and Lys might be derived from the downregulating of inflammatory mediators.

키워드

fermented porcine placenta inflammatory cytokine caspase-1 nitric oxide forced swimming test