학술논문
Mitophagy stimulation as a novel strategy for the treatment of mitochondrial diseases
이용수 5
- 영문명
- Mitophagy stimulation as a novel strategy for the treatment of mitochondrial diseases
- 발행기관
- 대한의학유전학회
- 저자명
- Kang-Min Lee Jeanho Yun
- 간행물 정보
- 『대한의학유전학회지』제19권 제2호, 49~56쪽, 전체 8쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2022.12.31
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국문 초록
영문 초록
Mitophagy, the selective degradation of damaged or surplus mitochondria using core autophagy machinery, plays an es-sential role in maintaining cellular mitochondrial function. Impaired mitophagy is closely linked to various human diseases, including neurodegenerative diseases, cardiovascular diseases, cancers and kidney disease. Defective mitophagy induces the accumulation of damaged mitochondria and thereby results in a decline in cellular survival and tissue function. Accordingly, enhancement of mitophagy has been proposed as a novel strategy for the treatment of human diseases closely linked to mi-tochondrial dysfunction. Recent studies showing that the stimulation of mitophagy has a therapeutic effect on several disease models highlight the possibility of disease treatment using mitophagy. The development of mitophagy inducers with toxicity and the identification of molecular mechanisms will enable the clinical application of mitophagy-based treatments.
목차
Introduction
Mitophagy Defects in Human Diseases
Therapeutic Effect of Mitophagy Stimulation
Concluding remarks/prospective
Acknowledgements
Authors’ Contributions
References
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- Mitophagy stimulation as a novel strategy for the treatment of mitochondrial diseases
- Variant of CHD1 gene resulting in a Korean case of Pilarowski-Bjornsson syndrome
- Genetic diagnosis of systemic autoinflammatory diseases and underlying primary immunodeficiency
- The first Korean case of 2p15p16.1 microdeletion syndrome, characterized by facial dysmorphism, developmental delay, and congenital hypothyroidism
- Prospective evaluation of the clinical utility of whole-exome sequencing using buccal swabbing for undiagnosed rare diseases
- SLC9A6 -related developmental and epileptic encephalopathy with spike-and-wave activation in sleep: A case report
- Co-occurrence of both maternally inherited neurofibromatosis type 1 and Lesch-Nyhan disease in a child with severe neurodevelopmental impairment
- Clinical application of prenatal chromosomal microarray
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