Wistar 흰쥐에서 안드로겐 수용체 증가를 통한 비수리 추출물의 남성 갱년기 개선 효과

• 영문명: Ameliorating Effect of Lespedeza cuneata Extract on Male Menopause in Wistar Rats by Increasing Androgen Receptor
• 발행기관: 대한약학회
• 저자명: 이성 정세영 김창희 김형지 모상준 최순향 김은영 강다혜 김은진 안진철
• 간행물 정보: 『약학회지』제66권 제6호(2022년), 316~323쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2022.12.30

영문 초록

Male menopause, also referred to as late-onset hypogonadism or andropause, is a clinical syndrome characterized by sexual dysfunction, depressive disorder, and insomnia secondary to a testosterone deficiency in older men. Lespedeza cuneata, which belongs to the Fabaceae family, possesses several biological properties, including antiinflammatory, anti-oxidant, and antidiabetic effects. We investigated the inhibitory effect of standardized L. cuneata extract (LCE) on andropause symptoms in vivo. LCE administration significantly increased serum levels of total testosterone without any effects on serum estrogen levels. Additionally, LCE significantly increased serum 17-beta hydroxysteroid dehydrogenase 13 protein levels and reduced levels of sex hormone-binding globulin (SHBG), a protein that blocks free testosterone movement into the cytosol. LCE significantly upregulated the expression of cAMP response element binding protein and androgen receptor (AR), which functions as a transcription factor to stimulate spermatogenesis-associated genes and results in increased numbers of AR-positive cells, such as Leydig and Sertoli cells in the testis. To summarize, LCE administration increases serum testosterone, reduces SHBG levels and upregulates AR expression. Therefore, LCE may be useful as alternative therapy for andropause in older men.

목차

서론(Introduction)

방법(Methods)

결과(Results)

고찰(Discussion)

결론(Conclusion)

Acknowledgments

Conflict of Interest

References

키워드

Androgen receptor Andropause Male menopause Lespedeza cuneata Testosterone