자궁경부암 근접치료 시 선량 검증 프로그램을 통한 임상적 위험성 평가

• 영문명: Clinical Risk Evaluation Using Dose Verification Program of Brachytherapy for Cervical Cancer
• 발행기관: 대한방사선과학회(구 대한방사선기술학회)
• 저자명: 강동진 신영주 강진규 정재용 이우진 백태성 이보람
• 간행물 정보: 『방사선기술과학』제45권 제6호, 553~560쪽, 전체 8쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2022.12.31

영문 초록

The purpose of this study is to evaluate the clinical risk according to the applicator heterogeneity, mislocation, and tissue heterogeneity correction through a dose verification program during brachytherapy of cervical cancer. We performed image processing with MATLAB on images acquired with CT simulator. The source was modeled and stochiometric calibration and Monte-Carlo algorithm were applied based on dwell time and location to calculate the dose, and the secondary cancer risk was evaluated in the dose verification program. The result calculated by correcting for applicator and tissue heterogeneity showed a maximum dose of about 25% higher. In the bladder, the difference in excess absolute risk according to the heterogeneity correction was not significant. In the rectum, the difference in excess absolute risk was lower than that calculated by correcting applicator and tissue heterogeneity compared to the water-based calculation. In the femur, the water-based calculation result was the lowest, and the result calculated by correcting the applicator and tissue heterogeneity was 10% higher. A maximum of 14% dose difference occurred when the applicator mislocation was 20 mm in the Z-axis. In a future study, it is expected that a system that can independently verify the treatment plan can be developed by automating the interface between the treatment planning system and the dose verification program.

목차

Ⅰ. 서 론

Ⅱ. 대상 및 방법

Ⅲ. 결 과

Ⅳ. 고 찰

Ⅴ. 결 론

REFERENCES

키워드

전산모사 알고리즘 선량 검증 프로그램 어플리케이터 초과 절대 위험 이차 암 위험 Monte-Carlo algorithm Dose verification Program Applicator Excess absolute risk Secondary cancer risk