학술논문
Limited field adaptive radiotherapy for glioblastoma: changes in target volume and organ at risk doses
이용수 15
- 영문명
- 발행기관
- 대한방사선종양학회
- 저자명
- Ö znur Ş enkesen Evrim Tezcanlı Mehmet Ufuk Abacıoğ lu Zeynep Ö zen Derya Ç ö ne Halil Kü ç ü cü k Evren Ozan Gö ksel Alptekin Arifoğ lu Meriç Ş engö z
- 간행물 정보
- 『대한방사선종양학회지』제40권 제1호, 9~19쪽, 전체 11쪽
- 주제분류
- 의약학 > 종양학
- 파일형태
- 발행일자
- 2022.03.30
4,120원
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국문 초록
영문 초록
Objective: This study aimed to investigate the tumor volume changes occurring during limited-field radiotherapy (RT) for glioblastoma patients and whether a volume-adapted boost planning approach provided any benefit on tumor coverage and normal tissue sparing.
Materials and Methods: Twenty-four patients underwent simulation with magnetic resonance (MR) and computed tomography (CT) scans prior to RT (MR_initial, CT_initial) and boost treatment (MR_adapt, CT_adapt). For the boost phase, MR_initial and MR_adapt images were used to delineate GTV2 and GTV2_adapt, respectively. An initial boost plan (Plan_initial) created on CT_initial for PTV2 was then reoptimized on CT_adapt by keeping the same optimization and normalization values. Plan_adapt was generated on CT_adapt for PTV2_adapt volume. Dose volume histogram parameters for target volumes and organs-at-risk were compared using these boost plans generated on CT_adapt. Plan_initial and Plan_adaptive boost plans were summed with the first phase plan and the effect on the total dose was investigated.
Results: Target volume expansion was noted in 21% of patients while 79% had shrinkage. The average difference for the initial and adaptive gross tumor volume (GTV), clinical target volume (CTV), and planning target volume (PTV) volumes were statistically significant. Maximum dose differences for brainstem and optic chiasm were significant. Healthy brain tissue V10 and ipsilateral optic nerve maximum doses were found to decrease significantly in Plan_adaptive.
Conclusion: Results of this study confirm occurrence of target volume changes during RT for glioblastoma patients. An adaptive plan can provide better normal tissue sparing for patients with lesion shrinkage and avoid undercoverage of treatment volumes in case of target volume expansion especially when limited-fields are used.
목차
Introduction
Materials and Methods
Results
Discussion and Conclusion
Conflict of Interest
References
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- Trends in the use of radiation for meningioma across the United States
- Immunomodulatory effect of splenectomy in lung cancer mouse xenograft models receiving radiation therapy
- Limited field adaptive radiotherapy for glioblastoma: changes in target volume and organ at risk doses
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