학술논문
PIVKA-II as a surrogate marker for prognosis in patients with localized hepatocellular carcinoma receiving stereotactic body radiotherapy
이용수 20
- 영문명
- 발행기관
- 대한방사선종양학회
- 저자명
- Ick Joon Cho Jae-Uk Jeong Taek-Keun Nam Young-Eun Joo Sung-Bum Cho Yong-Hyub Kim Ju-Young Song Mee Sun Yoon Sung-Ja Ahn Woong-Ki Chung
- 간행물 정보
- 『대한방사선종양학회지』제40권 제1호, 20~28쪽, 전체 9쪽
- 주제분류
- 의약학 > 종양학
- 파일형태
- 발행일자
- 2022.03.30
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국문 초록
영문 초록
Purpose: This study aimed to determine the correlation between protein induced by vitamin K absence or antagonist-II (PIVKA-II) and stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC).
Materials and Methods: Sixty-one patients received SBRT between 2015 and 2020 with a median dose of 48 Gy (range, 39 to 60 Gy) with a median of 4 fractions. Changes in tumor markers before and after SBRT were analyzed.
Results: The median follow-up period was 31 months (range, 12 to 64 months). The estimated 2-year in-field failure-free survival, progression-free survival (PFS), and overall survival rates were 82.0%, 39.3%, and 96.7%, respectively. Patients with decreased PIVKA-II levels through SBRT had significantly few in-field failures (p = 0.005). Patients with PIVKA-II levels of ≤25 mAU/mL after SBRT had significantly long PFS (p = 0.004).
Conclusion: PIVKA-II could be a useful surrogate marker for response or survival outcomes in patients with localized HCC receiving SBRT.
목차
Introduction
Materials and Methods
Results
Conflict of Interest
Acknowledgements
References
해당간행물 수록 논문
- Long-term outcomes of low-dose radiotherapy in Kasabach-Merritt syndrome
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- Optimal positive lymph node ratio showing the benefit of postoperative radiotherapy in pathologic N2 non-small cell lung cancer: an exploratory study using the Surveillance, Epidemiology, and End Results data
- Trends in the use of radiation for meningioma across the United States
- Immunomodulatory effect of splenectomy in lung cancer mouse xenograft models receiving radiation therapy
- Limited field adaptive radiotherapy for glioblastoma: changes in target volume and organ at risk doses
- PA1 cells containing a truncated DNA polymerase β protein are more sensitive to gamma radiation
- PIVKA-II as a surrogate marker for prognosis in patients with localized hepatocellular carcinoma receiving stereotactic body radiotherapy
- Reviewing the potential role of radiation therapy in gallbladder cancer: an update
- Comment on “Abscopal effect in the radio and immunotherapy”
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