유색감자 추출물의 항돌연변이 및 항암 활성

• 영문명: Antimutagenic Effect and Cytotoxicity to Human Cancer Cell Lines of Colored Potato Extracts
• 발행기관: 한국작물학회
• 저자명: 박영은(Young Eun Park) 정진철(Jin-Cheol Jeong) 조현묵(Huyn-Mook Cho) 황영선(Young-Sun Hwang) 이현진(Hyeon-Jin Lee) 이수진(Su-Jin Lee) 박은선(Eun-Sun Park) 고은아(Eun-A Ko) 김남솔(Nan-Sol Kim) 임정대(Jung-Dae Lim) 최수산나(Su-San-Na Choi) 정명근(Myoung-Gun Choung)
• 간행물 정보: 『한국작물학회지』제53권 제1호, 75~84쪽, 전체 10쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2008.03.30

영문 초록

Colored potatoes are an excellent source ofdietary polyphenols including anthocyanins. Generaly, antho-cyanins from fruits and vegetables exhibit anti-carcinogenesisand anti-cancer propertiesin vitrotest. This experimentwas conducted to know the effects of colored potato extractscontained anthocyanins on antimutagenic activity and anti-cancer activity to six human cancer cell lines containingLNCaP (androgen-dependent) prostate cancer cells. Extractsof thre colored potatoes (Hongyoung, Jayoung and Jasim)and the white potato (Superior) cultivars were used in thismutagenicities induced by direct mutagen such as 4-nitro-quinoline-1-oxide (4-NQO) and another indirect mutagensof bezo(a)pyrene (BaP). Also, the xtracts of Hoyoungand Jayoung showed higherantimutagenic activity thanJasim and Superior against o direct or indirect mutagenon both strains of TA98 and TA100. The activity of growth-inhibitory of extract of four potato cultivars were screenedby SRB (sulphorhodamine B) method on diverse humancancer cells representing different types of cancers. Amongthe extract of four potato cultivars, the extract of Jasimshowed moderate inhibition on proliferation of LNCaP,ACHN and MOLT-4F cells and did not inhibit he proli-feration of other cancer cells. On the other hand, extractof Superior did not inhibit the proliferation of any testedcancer cell ines. However, the extracts of Hongyoung andJayoung inhibited the proliferation of cancer cells withGI50 values ranging from 2.5 to 30 g/mL. On the basisμof the GI50 values, it is clear that LNCaP cells were moresensitive to extracts of colored potato cultivars than othercancer cells. The extract of Jayoung at 30 g/mL wereμmore active and inhibited cell proliferation, and inducedapoptosis in LNCaP cells. This result revealed that he xtractsof colored potatoes are expected to be good candidate forntimutagenic and anticanceragent.

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colored potato antimutagenic activity anticancer activity anthocyanin Jayoung