항바이러스제 점안에 의한 안독성

• 영문명: Ocular Toxicity Induced by Topical Antivirals: Clinical Manifestation and Follow-up of 6 Case Series
• 발행기관: 대한검안학회
• 저자명: 이지혜(Ji Hye Lee) 조양경(Yang Kyung Cho)
• 간행물 정보: 『Annals of optometry and contact lens』Vol.20 No.2, 79~83쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.06.30

영문 초록

Purpose: We report six cases of ocular toxicity following treatment with topical antiviral agents for herpes epithelial keratitis. Case summary: Among 47 patients with a diagnosis of herpes simplex epithelial keratitis treated between July 1, 2018, and June 10, 2020, five patients treated with 1% trifluridine and one patient treated with 3% acyclovir showed ocular toxicity. These six patients showed repeated aggravation and slow recovery throughout the period of treatment with topical antiviral agents over 1 month. Total duration of treatment was 6.0 ± 1.8 weeks since the additional diagnosis of ocular toxicity due to antivirals in these six patients. Conclusions: Use of topical antiviral agents for extended periods showed ocular toxicity. In particular, 1% trifluridine showed frequent toxicity in the cornea, conjunctiva, and eyelid, which required special care and attention.

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키워드

Acyclovir Contact dermatitis Toxic keratoconjunctivitis Trifluridine