학술논문
췌장신경내분비종양 항암화학요법의 현행 급여기준에 대한 검토 및 개선
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- 영문명
- Formulary review and update for the anti-cancer drugs used in pancreatic neuroendocrine tumors
- 발행기관
- 한국보건사회약료경영학회
- 저자명
- 박은지(Eun Ji Park) 이영숙(Young Sook Lee)
- 간행물 정보
- 『한국보건사회약료경영학회지』제3권 제2호, 69~80쪽, 전체 12쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2011.12.30
4,240원
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이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
OBJECTIVES Anti-cancer drug formulary needs to be periodically updated based on current clinical trial data. This study is to review current drug formulary for pancreatic neuroendocrine tumors (PNET) and then propose the updated reimbursement criteria. METHODS Based on the current anti-cancer drug formulary, the drugs on the list and newly approved drugs for the treatment of PNET were reviewed in the context of the evidence-based medicine practice. The oncology textbooks, narrative review articles and clinical practice guidelines were reviewed. PubMed search for the primary literature and systematic review was performed with MeSH terms (pancreatic neuroendocrine tumors, islet cell carcinoma, and gastroenteropancreatic neuroendocrine tumor). The medical articles were critically appraised with the literature evidence strength levels and the final new criteria were proposed. RESULTS Only one anti-cancer drug, sunitinib, had been recently approved for the PNET. Three randomized controlled trial literatures (evidence level category 2) were viewed to be selected to improve formulary. The anti-cancer drugs which usage was supported by the category 2 articles were interferon- alpha, sunitinib and everolimus. The latter two drugs that were not on the list yet should be included and their criteria should be specified by the patient characteristics in the clinical literature. CONCLUSIONS Sunitinib and everolimus should be listed on the anti-cancer drug formulary with a reimbursement criteria of “treatment of unresectable or metastatic, well-differentiated pancreatic neuroendocrine tumors with disease progression in adults” as described in the approved indication and published clinical trial data.
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