전 국민 대상 DUR의 민감도 및 특이성 점검

• 영문명: Evaluation of the sensitivity and specificity of national DUR program : focused on drug-drug interaction
• 발행기관: 한국보건사회약료경영학회
• 저자명: 강현아(Hyeun Ah Kang) 김해숙(Hae Sook Kim) 오청환(Chung Hwan Oh) 신현택(Hyun Taek Shin)
• 간행물 정보: 『한국보건사회약료경영학회지』제3권 제1호, 16~22쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.06.30

영문 초록

Introduction To improve patient safety and appropriateness of drug usage in Korea, a DUR program has been operated by HIRA since 2008. However, the quality of the program has never been verified although it is the only DUR processing tool used nationwide. Purpose The aim of this study is to examine the sensitivity and specificity of the program focused on drug-drug interactions within and between prescriptions. Method A total of 655,928 prescriptions issued in a 650-bed hospital for 6 months were analyzed using HIRA-DUR program and a drug-interaction detection module developed by DIF-KOREATM (DI-module). In this study, the DI-module was adopted as a golden standard because it has been made up with a number of reliable references recommended by OBRA’90 and complemented with information on korean local drugs. Result The sensitivity and specificity of the HIRA program in detecting drug-interaction were 17.99% and 99.83%, respectively, when compared with the DI-module. Discussion Reasons for the differences could be speculated as follows; i) There were medicines not been checked by the HIRA program because they were not in national formulary or they were combination drugs. ii) The program did not include some pairs of active ingredients related to possible drug interaction because KFDA announced a list of them partially. iii) Certain dosage strength and forms of some KFDA-announced active ingredients were left out from the possible drug-interaction list of the HIRA program. Conclusion It is concluded that an effort to update the most recent information and to manage the possible drug-interaction list should be made on regular base by related organizations such as HIRA and KFDA to improve safety of patients in drug use.

목차

서 론

연구방법

연구결과

고 찰

결 론

참고문헌

키워드

DUR drug interaction module sensitivity