학술논문
밀러-피셔증후군과 비커스태프 뇌줄기염의 임상적 특징
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- 영문명
- Clinical Characteristics of Miller-Fisher Syndrome and Bickerstaff Brainstem Encephalitis
- 발행기관
- 대한검안학회
- 저자명
- 김민하(Min Ha Kim) 서유리(Yuri Seo) 한승한(Sueng-Han Han) 한진우(Jinu Han)
- 간행물 정보
- 『Annals of optometry and contact lens』Vol.19 No.4, 103~109쪽, 전체 7쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2020.12.30
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국문 초록
영문 초록
Purpose: To investigate the clinical characteristics of patients clinically diagnosed with anti-GQ1b antibody syndrome.
Methods: From November 2005 to July 2019, we retrospectively reviewed the medical records of 52 patients diagnosed with Miller-Fisher syndrome, Bickerstaff brainstem encephalitis or anti-GQ1b antibody syndrome. Symptom including acute ophthalmoplegia, ataxia, hyporeflexia and other neurologic features were reviewed. Laboratory results including cerebrospinal fluid (CSF) analysis and anti-ganglioside antibodies were also analyzed.
Results: Among 52 patients, 40 were diagnosed with classic Miller-Fisher syndrome, 3 patients were Guillain-Barré syndrome with ophthalmoparesis, 1 patient was acute ophthalmoparesis without ataxia, 2 patients were acute ataxic neuropathy, and 6 patients were diagnosis with Bickerstaff brainstem encephalitis. Thirty five patients were male (67.3%), the mean age of onset was 39.3 ± 16.7 years, and average follow-up duration was 9.6 ± 15.9 months. Forty-four patients (84.6%) showed preceding infection, and upper respiratory infection was more common than gastrointestinal infection. Forty-nine patients (94.2%) showed ophthalmoplegia, 48 patients (92.3%) showed ataxia and hyporeflexia was presented in 43/51 patients (84.3%). Other than classic symptoms, dysarthria (21/52, 40.4%), dizziness (27/52, 51.9%), and paresthesia (23/52, 44.2%) was observed. Among 48 patients who underwent CSF analysis, 11 patients (22.9%) showed albumino-cytologic dissociation. Only 12 patients (23.1%) had positive anti-ganglioside antibodies.
Conclusions: Anti-GQ1b antibody syndrome is not easy to differentiate from other diseases, careful physical examination and history taking is necessary to make correct diagnosis. The recognition of accompanying symptoms and signs could facilitate early and exact diagnosis of anti-GQ1b antibody syndrome.
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