Protective Effects of Ramie (Boehmeria nivea) against Oxidative Stress in C6 Glial Cells

• 발행기관: 한국자원식물학회
• 저자명: Xiaoning Wang Sunghun Cho Ho Bang Kim Yong-Su Jung Eun Ju Cho Sanghyun Lee
• 간행물 정보: 『한국자원식물학회지』제28권 제6호, 675~681쪽, 전체 7쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2015.12.30

영문 초록

β amyloid protein (Aβ) plays a critical role in the pathogenesis of Alzheimer s disease (AD) and possibly in Aβ -induced mitochondrial dysfunction and oxidative stress. Aβ can directly cause reactive oxygen species (ROS) production. Overproduction of ROS is considered to be involved in the pathogenesis of neurodegeneration of AD. Here, we investigated 9 kinds of ramie (Boehmeria nivea, (L.) Gaud., BN; hereafter denoted as BN) for their protective action against oxidative stress in a cellular system using C6 glial cells. We observed loss of cell viability and high levels of ROS generation after treatment with hydrogen peroxide (H2O2) and Aβ25-35. However, treatments with BN extracts led to an increase in cell viability and decrease in ROS production induced by H2O2 and Aβ25-35. In particular, the extracts of BN-01 (seobang variety from Seocheon) and BN-09 (local variety from Yeonggwang) showed excellent anti-oxidative properties. This indicates that BN extracts could prevent neurodegeneration by reducing oxidative stress in cells.

목차

Introduction

Materials and Methods

Results and Discussion

Acknowledgment

References

키워드

Boehmeria nivea Alzheimer’s disease Reactive oxygen species C6 glial cell