Inhibition Activity of Plants on IgE-mediated Degranulation of RBL-2H3 Cells

• 발행기관: 한국자원식물학회
• 저자명: Seung-Eun Lee Hye-Gwang Jeong Dae-Young Lee Jeong-Hoon Lee Jehun Choi Geum-Soog Kim Hyung-Jun Noh Jae-Won Lee Seung-Yu Kim Young-Sup Ahn
• 간행물 정보: 『한국자원식물학회지』제28권 제6호, 718~726쪽, 전체 9쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2015.12.30

영문 초록

In this study, the inhibitory activities of fifty plant extracts on IgE-mediated degranulation in the rat basophilic leukemia cell line (RBL-2H3 cells) were measured; the release of interleukin (IL)-4 and β-hexosaminidase from IgE-sensitized cells treated with the plant extracts was measured; and the effects of the plant extracts on cell viability were tested. The results of the analysis of plant extracts at 20 ㎍/㎖, including the aerial part of Magnolia sieboldii K. Koch, exhibited suppressive activities upon the release of IL-4. Furthermore, several plant extracts including methanol extracted from Lindera erythrocarpa Makino (aerial part) at the same concentration significantly inhibited the release of β-hexosaminidase. Twenty-six of the plant extracts, including methanol extract of Weigela subsessilis (Nakai) L. H. Bailey (branch), showed a cell proliferation effect of over 80% at 100 ㎍/㎖. In conclusion, the results suggest that the leaf/stem of Geum japonicum Thunb. and the stamen/ovary of Nelumbo nucifera Gaertn., which exhibited effective inhibition on β-hexosaminidase release and IL-4 release from mast cells and showed high cell viability, could be useful candidates as anti-allergy materials.

목차

Introduction

Materials and Methods

Results and Discussion

Acknowledgment

References

키워드

Allergy Degranulation β-hexosaminidase Mast cell Interleukin-4