Anti-oxidant Effect of Agastache rugosa on Oxidative Damage Induced by H₂O₂ in NIH 3T3 Cell

• 발행기관: 한국자원식물학회
• 저자명: Se Chul Hong Jin Boo Jeong Gwang Hun Park Jeong Sook Kim Eul Won Seo Hyung Jin Jeong
• 간행물 정보: 『한국자원식물학회지』제22권 제6호, 498~505쪽, 전체 8쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2009.12.31

영문 초록

The plant Agastache rugosa Kuntze has various physiological and pharmacological activities. Especially, it has been regarded as a valuable source for the treatment of anti-inflammatory and oxidative stress-induced disorders. However, little has been known about the functional role of it on oxidative damage in mammalian cells by ROS. In this study, we investigated the DPPH radical, hydroxyl radical, hydrogen peroxide and intracellular ROS scavenging capacity, and Fe^2+ chelating activity of the extracts from Agastache rugosa. In addition, we evaluated whether the extract can be capable of reducing H₂O₂-induced DNA and cell damage in NIH 3T3 cells. These extracts showed a dose-dependent free radical scavenging capacity and a protective effect on DNA damage and the lipid peroxidation causing the cell damage by H₂O₂. Therefore, these results suggest that Agastache rugosa is useful as a herbal medicine for the chemoprevention against oxidative carcinogenesis.

목차

INTRODUCTION

MATERIAL AND METHODS

RESULT AND DISCUSSION

LITERATURE CITED

키워드

Agastache rugosa Kuntze Lipid peroxidation Oxidative cell death Oxidative DNA damage Reactive oxygen species