학술논문
Combination of Grapefruit and Rosemary Extracts Has Skin Protective Effect through MMPs, MAPKs, and the NF-κB Signaling Pathway In Vitro and In Vivo UVB-exposed Model
이용수 4
- 영문명
- 발행기관
- 한국자원식물학회
- 저자명
- Yeo-Cho Yoon Hee-Jeong Choi Ji-Hyun Park Nurud Diniyah Hyun-A Shin Mi-Yeon Kim
- 간행물 정보
- 『한국자원식물학회지』제32권 제6호, 633~643쪽, 전체 11쪽
- 주제분류
- 농수해양 > 기타농수해양
- 파일형태
- 발행일자
- 2019.12.30
4,120원
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국문 초록
영문 초록
Long-term ultraviolet (UV) exposure accelerates the phenomenon of skin photo-aging by activating collagenase and elastase. In this study, we aimed to investigate the effects of a combination of grapefruit and rosemary extracts (cG&Re) on UVB-irradiated damage in HaCaT cells and dorsal mouse skin. In HaCaT cells, cG&Re recovered UVB-reduced cell viability and inhibited protein expression of mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinases (p-Erk), c-Jun N-terminal kinases (p-JNK), and a class of MAPKs (p-P38). Also, cG&Re suppressed UVB-induced collagen and elastin degradation by decreasing matrix metalloproteinases (MMPs) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) expression, which is a transcription factor. Similar results were observed in dorsal mouse skin. Taken together, our data indicate that cG&Re prevent UVB-induced skin photo-aging due to collagen/elastin degradation via activation of MAPKs, MMPs, and the NF-κB signaling pathway in vitro and in vivo.
목차
Introduction
Materials and Methods
Results
Discussion
References
키워드
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