스타틴 처방 후 연령에 따른 저밀도 콜레스테롤의 목표 도달률 분석

• 영문명: Analysis of Target Achievement of Low-Density Lipoprotein Cholesterol according to Age after Statin Prescription
• 발행기관: 대한임상노인의학회
• 저자명: 최선(Seon Choe) 신지원(Jiwon Shinn) 김헌성(Hun-Sung Kim) 김주한(Ju Han Kim)
• 간행물 정보: 『대한임상노인의학회지』대한임상노인의학회지 제21권 제2호, 81~87쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2020.12.30

영문 초록

Background: The purpose of this study was to determine the target achievement level of low-density lipoprotein cholesterol (LDL-C) according to age and glomerular filtration rate (GFR) in patients taking LipilouⓇ, a generic formulation of atorvastatin, in clinical practice. Methods: This study was an electronic medical record-based study of patients prescribed LipilouⓇ for more than 2 months at Seoul National University Hospital between 2012 and 2018. The target achievement level of LDL-C was less than 70 mg/dL or 100 mg/dL, depending on the patient’s age. The target LDL-C achievement level according to renal function was evaluated in patients older than 60 years of age. Results: A total of 1,209 patients were included in this study. Target LDL-C achievement levels less than 70 mg/dL or 100 mg/dL showed a significant increase with age (P＜0.001). For patients in their 60s, a target achievement level of less than 100 mg/dL increased significantly as the GFR decreased (P＜0.05). Conclusion: Allowing for an increased target LDL-C achievement level may be important to prevent cardiovascular disease. Considering that elderly patients respond differently to treatments and follow different prognoses, as well as exhibiting individual differences, physicians must carefully plan treatments involving statins.

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키워드

Cholesterol Dyslipidemias Glomerular filtration rate HMG-CoA reductase inhibitor Hyperlipidemias