학술논문
Anti-oxidative effect of baicalin in lipopolysaccharide-induced hippocampus damage
이용수 8
- 영문명
- 발행기관
- 한국예방수의학회
- 저자명
- Dong-Ju Park Ju-Bin Kang Phil-Ok Koh
- 간행물 정보
- 『Journal of Preventive Veterinary Medicine』Vol.44, No.3, 118~123쪽, 전체 6쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2020.09.30
4,000원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
Baicalin is a flavonoid compound with many advantages, including anti-inflammatory agents and antioxidants. Lipopolysaccharide (LPS) is an endotoxin that induces neuronal damage through inflammatory response and oxidative stress reaction. This study was investigated the protective effects of baicalin on the oxidative stress and histopathological changes caused by LPS in hippocampus. Adult mice were divided into four groups; vehicle-treated, baicalin-treated, LPS-treated, and LPS and baicalin co-treated animals. Baicalin (10 mg/kg/day) and/or LPS (250 μg/kg/day) were intraperitoneally administered for seven consecutive days, and body weight was measured. Reactive oxygen species (ROS) level and lipid peroxidation level in the hippocampus were examined. Histopathological study was performed using hematoxylin and eosin staining manuals. LPS treatment decreased body weight and increased ROS and oxidative stress in the hippocampus. However, co-treatment with baicalin alleviated these changes caused by LPS. Severe histopathological changes were observed in the hippocampus of LPS-treated animals. Baicalin co-treatment attenuated the changes and preserved neuronal cells from LPS damage. These results showed that baicalin suppresses LPS-induced neuronal damage by alleviating oxidative stress in the hippocampus. Thus, this study demonstrated that baicalin exerts protective effects against LPS-induced oxidative stress in hippocampus.
목차
서 론
재료 및 방법
결 과
고 찰
REFERENCES
해당간행물 수록 논문
- Comparison between three fixed anaesthesia protocols in rabbits
- Genome sequences of porcine parvovirus 2 from the lung tissue of aborted pig fetuses in the Republic of Korea
- Evaluation of antibacterial effect against major food poisoning bacteria and skin irritation test of Curcuma aromatica Salisb. extract
- Antibody responses after vaccination against equine influenza virus in the Republic of Korea in 2019
- Seroprevalence of the swine influenza A virus in domestic pigs in the Republic of Korea
- Anti-oxidative effect of baicalin in lipopolysaccharide-induced hippocampus damage
- Geographical weighted Poisson regression model of pig farm vehicle movements for the 2016 foot and mouth disease epidemics in South Chungcheong
- Construction of Salmonella Enteritidis ghosts manipulated by the λ phage holin-endolysin system that express HA1 domain of hemagglutinin of influenza H1N1 virus
- Production of recombinant new canine parvovirus 2a viral protein 2 in SF9 cells using a baculovirus expression system
참고문헌
관련논문
의약학 > 의학일반분야 BEST
더보기의약학 > 의학일반분야 NEW
- Finite element analysis of the effects of different archwire forms and power arm positions on maxillary incisors in en masse retraction using fixed lingual orthodontic appliances
- Genetic polymorphisms in external apical root resorption and orthodontic tooth movements: A systematic review
- Upper airway dimensions and craniofacial morphology: A correlation study using cone beam computed tomography
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!