PHMG (polyhexamethylene guanidine) 흡입독성참고치 산출을 통한 가습기살균제 노출등급 분류 및 특성

• 영문명: Classification and Characterization of Exposure Rating in Humidifier Disinfectants through Calculation of PHMG Reference Concentration
• 발행기관: 한국환경보건학회
• 저자명: 김은채(Eunchae Kim) 류현수(Hyeonsu Ryu) 박진현(Jinhyeon Park) 최영태(Youngtae Choe) 허정(Jung Heo) 이슬아(Seula Lee) 조은경(Eun-Kyung Jo) 최윤형(Yoon-Hyeong Choi) 조만수(Mansu Cho) 양원호(Wonho Yang)
• 간행물 정보: 『1. 한국환경보건학회지』제46권 제3호, 335~343쪽, 전체 9쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2020.06.30

영문 초록

Objectives: The Korean Ministry of Environment has identified cases of people suspected of suffering lung disease potentially caused by polyhexamethylene guanidine (PHMG) used in humidifier disinfectants (HDs). Exposure assessment for the HDs was conducted using a questionnaire during face-to-face interview. The main purposes of this study were to develop a methodology to effectively classify levels of exposure to HDs based on a questionnaire. Methods: We first identified the overall participants’ exposure characteristics by HD exposure levels; Second, we selected misclassified subjects and investigated characteristics of overestimated and underestimated subjects, focusing on exposure cases to PHMG-containing HDs. An inhalation reference concentration (RfC) for PHMG was produced on the basis of inhalation toxicity values. We made a cross-tabulation of the exposure classes (Exposure classes 1-to-4) by clinical classes based on the RfC. When the value of the exposure class minus the clinical class was 0 or 1, we assumed these were true values. When the value was ≥2 and ≤ −2, we assigned these cases to the overestimation group and underestimation group, respectively. Results: The overestimated group may have already recovered and responded excessively due to psychological anxiety or in order to receive compensation. On the other hand, relatively high mortality rates and surrogate responses for those under 10 years of age may have resulted in inaccurate exposure assessment for underestimated groups. For the characteristics of exposure, it was shown that for the underestimated group, the exposure was relatively weaker than the overestimated group, even though a high overall clinical rating was determined. Conclusions: This study may suggest ways to reduce bias and overcome the limitations of current HD exposure assessment.

목차

I. 서 론

II. 연구 방법

III. 연구 결과

IV. 고 찰

V. 결 론

감사의 글

References

키워드

Humidifier disinfectant exposure assessment past exposure questionnaire misclassification