Serum testosterone is correlated with higher bone mineral density in the low serum 25-hydroxyvitamin D concentration among healthy middle-aged and older Korean men

• 발행기관: 대한기능의학회
• 저자명: Jung-Min Choi Eun-Sub Lee Nam-Seok Joo
• 간행물 정보: 『Journal of Korean Institute for Functional Medicine』Vol.3 No. 1, 1~8쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2020.05.01

영문 초록

Background: Serum testosterone and 25-hydroxyvitamin D [25(OH)D] have important roles in the maintenance of bone mineral density (BMD). We compared the BMD according to the serum testosterone with serum 25(OH)D concentration. Methods: A total of 414 subjects of middle-aged males were selected with the data of serum testosterone, 25(OH)D, and BMD by Dual-Energy-X ray-Absorptiometry. Before comparing the femur neck BMD (FNBMD), total hip BMD (THBMD), and lumbar spine BMD (LSBMD), the 25(OH)D was divided into two groups by the median concentration (37.5 nmol/L). In addition, the serum testosterone was also divided into three groups with tertile. Each BMD was compared, according to the groups of serum 25(OH)D and testosterone, by relevant variables adjustment. Results: Serum testosterone and each BMD showed positive correlations in the low 25(OH)D concentration (<37.5 nmol/L). In addition, LSBMD was significantly higher in the top tertile of serum testosterone with the low 25(OH)D concentration (<37.5 nmol/L). The odds of having the highest tertile of FNBMD and THBMD in the top tertile of serum testosterone were 2.75 (95% confidence interval [CI]; 1.11-6.85) and 2.76 (95% CI; 1.09-6.96), respectively, whereas, in the LSBND, the significant odds ratio being in the 2nd tertile of serum testosterone (OR=4.02, 95% CI; 1.69-9.54), not in the highest tertile. Conclusion: Serum testosterone was significantly correlated to BMD in the lower concentration of 25(OH)D (<37.5 nmol/L), which may mean that the maintenance of serum testosterone concentration is important, at least in the lower serum 25(OH)D concentration to keep relatively higher BMD in the middle-aged males.

목차

Introduction

Materials and Methods

Results

Discussion

Conclusions

키워드

Testosterone Vitamin D Bone density