고삼 추출물의 과민성 방광에 미치는 효과 및 급성독성 연구

• 영문명: Effects on Overactive Bladder and Acute Toxicity of the Extracts of Sophora flavescens Aiton
• 발행기관: 대한약학회
• 저자명: 이현준(Hyun Jun Lee) 김미경(Mikyung Kim) 유경이(Kyung Yi You) 김희진(Hee Jin Kim) 정재훈(Jae Hoon Cheong)
• 간행물 정보: 『약학회지』제63권 제5호(2019년), 268~273쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2019.10.30

영문 초록

Overactive bladder (OAB) is a common disorder and is accompanied with high urinary frequency, nocturia and urinary incontinence which causes unconscious urine loss immediately after urination. It may affect quality of life, sleep and mental health. Extract of Sophora flavescens (SR) Aiton contains kurarinone which has been reported to activate BK Ca channel and may have role in ameliorating OAB. In this study, the effects of the SR extracts on OAB and acute toxicity were investigated. We prepared the SR extracts using 30% EtOH after water extraction. Then we conducted void experiment (10, 30, 100 mg/kg P.O) using spontaneously hypertensive rats (SHR) and WKY rats. The SR extracts decreased urine frequency in a dose-dependent manner. The results of acute toxicity test (500, 1000, 2000 mg/kg P.O), open field test (OFT), and rota-rod test did not show any significant difference compared to control group. These results indicate that the SR extracts may have a supportive role in OAB without a significant toxicity in low doses. Taken together, the SR extracts may be a good candidate for health functional food ameliorating OAB. However, in order to clarify these findings further investigation may be needed in the future.

목차

서 론(Introduction)

결 과(Results)

고 찰(Discussion)

결 론(Conclusion)

키워드

Overactive bladder Sophora flavescens Aiton spontaneously hypertensive rat void behavior acute toxicity