금속매염제인 초산구리의 세포독성에 대한 자귀나무잎 추출물의 보호 효과

• 영문명: Protective Effect of Albizzia julibrissin Leaf Extract on the Cytotoxicity Induced by Cupric Acetate Metallic Mordant
• 발행기관: 한국환경보건학회
• 저자명: 정정화(Jung-Hwa Chung) 임요섭(Yo-Sup Rim) 서영미(Young-Mi Seo)
• 간행물 정보: 『1. 한국환경보건학회지』제45권 제5호, 520~528쪽, 전체 9쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2019.10.30

영문 초록

Objectives: This study assessed the cytotoxicity of the metallic mordant cupric acetate (CA) and the protective effect of Albizzia julibrissin (AJ) leaf extract on CA-induced cytotoxicity in NIH3T3 fibroblasts. Methods: For this study, cell viability and antioxidative effects such as the inhibitory activity of lipid peroxidation (LP) and superoxide anion-radical (SAR) scavenging activity were assessed. Results: CA significantly decreased cell viability in a dose-dependent manner, and the XTT50 value was measured as 55.0 µM of CA. The cytotoxicity of CA was determined as highly toxic by Borenfreund and Puerner’s toxic criteria. The catalase antioxidant significantly increased cell viability diminished by CA-induced cytotoxicity in these cultures. Regarding the protective effect of AJ leaf extract on CA-induced cytotoxicity, AJ leaf extract remarkably increased the SAR scavenging ability and the inhibitory ability of LP. From these findings, it is suggested that oxidative stress is involved in the cytotoxicity of CA, and AJ leaf extract effectively protected CA-induced cytotoxicity via antioxidative effects. Conclusions: Natural resources like AJ leaf extract may be a putative therapeutic agent for treatment or alleviation of the toxicity induced by CA metallic mordant.

목차

I. 서 론

II. 연구 방법

III. 결 과

IV. 고 찰

V. 결 론

키워드

Albizzia julibrissin lipid peroxidation metallic mordant oxidative stress