Development of a Screening Algorithm for Alzheimer’s Disease Using Categorical Fluency and Confrontational Naming Abilities

• 영문명: Development of a Screening Algorithm for Alzheimer’s Disease Using Categorical Fluency and Confrontational Naming Abilities
• 발행기관: 대한노인정신의학회
• 저자명: Yeon Kyung Chi Ji Won Han Sunyoung Park Tae Hui Kim Jung Jae Lee Seok Bum Lee Joon Hyuk Park Jong Chul Youn Jeong Lan Kim Seung-Ho Ryu Jin Hyeong Jhoo Ki Woong Kim
• 간행물 정보: 『노인정신의학』노인정신의학 제23권 제1호, 28~32쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2019.04.30

영문 초록

Objective：Declines in naming ability and semantic memory are well-known features of early Alzheimer’s disease (AD). We developed a new screening algorithm for AD using two brief language tests : the Categorical Fluency Test (CFT) and 15-item Boston Naming Test (BNT15). Methods：We administered the CFT, BNT15, and Mini-Mental State Examination (MMSE) to 150 AD patients with a Clinical Dementia Rating of 0.5 or 1 and to their age- and gender-matched cognitively normal controls. We developed a composite score for screening AD (LANGuage Composite score, LANG-C) that comprised demographic characteristics, BNT15 subindices, and CFT subindices. We compared the diagnostic accuracies of the LANG-C and MMSE using receiver operating curve analysis. Results：The LANG-C was calculated using the logit of test scores weighted by their coefficients from forward stepwise logistic regression models : logit (case)=12.608-0.107×age+1.111×gender+0.089×education-0.314×HS 1st -0.362×HS 2nd +0.455×per- severation+1.329×HFCR 2nd -0.489×MFCR 1st -0.565×LFCR 3rd . The area under the curve of the LANG-C for diagnosing AD was good (0.894, 95% confidence interval=0.853-0.926 ; sensitivity=0.787, specificity=0.840), although it was smaller than that of the MMSE. Conclusion：The LANG-C, which is easy to automate using PC or smart devices and to deliver widely via internet, can be a good alternative for screening AD to MMSE.

목차

Introduction

Subjects and Methods

Results

Discussion

키워드

Alzheimer’s disease Boston Naming Test Categorical Fluency Test Mini-Mental State Examination Naming ability Screening Semantic memory