Optic Neuropathy Associated with Ethambutol in Koreans

• 발행기관: 대한안과학회
• 저자명: Sang Yul Choi Jeong Min Hwang
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.11 No.2, 106~110쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.12.30

영문 초록

Ethambutol is a useful first line antituberculous drug, but can cause significant visual impairment. In order to determine the clinical manifestations of optic neuropathy associated with ethambutol, and the margin of drug safety in Koreans, we investigated ten men and four women, diagnosed between 1995 and 1997 at Seoul Municipal Boramae Hospital as suffering from ethambutol toxicity. After determining their history, including the period during which ethambutol had been administered, and its dose, a complete eye examination was performed, including measurement of best-corrected visual acuity, pupillary examination, color vision, fundus examination and a test of visual field. Ocular ethambutol toxicity was observed at a dose as low as 12.3 mg/kg. Abnormal ophthalmic findings include decreased visual acuity and abnormal visual field, especially in the central scotoma, and abnormal color perception. In conclusion, ethambutol at a low dose can cause optic neuropathy, and for the early detection of this, a color vision test is important.

목차

Abstract

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

ethambutol optic neuropathy