TIGR Gene in Primary Open-angle Glaucoma and Steroid-induced Glaucoma

• 발행기관: 대한안과학회
• 저자명: Changwon Kee Byung Heon Ahn
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.11 No.2, 75~78쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.12.30

영문 초록

To identify TIGR gene mutation in two Korean pedigrees of primary open-angle glaucoma (POAG), and in 25 steroid-induced glaucoma patients, TIGR gene assay was performed. Genomic DNA was extracted from peripheral blood and the TIGR gene was amplified by polymerase chain reaction (PCR). The PCR amplification products were evaluated by single-stranded conformation polymorphism and direct DNA sequencing. In POAG families, not only those patients clinically diagnosed as glaucoma, but also most of their siblings, in whom glaucoma had not yet been detected, had a proline-to-serine (TCC-to-CCC) mutation in codon 334. However, no steroid-induced glaucoma patients showed TIGR gene mutation. TIGR gene mutation, in familial POAG, was found in a different codon from that previously reported. The TIGR gene does not, however, seem to be related to steroid-induced glaucoma.

목차

Abstract

INTRODUCTION

SUBJECTS AND METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

TIGR gene primary open-angle glaucoma steroid-induced glaucoma mutation