학술논문
Efficacy of the Mineral Oil and Hyaluronic Acid Mixture Eye Drops in Murine Dry Eye
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- 영문명
- 발행기관
- 대한안과학회
- 저자명
- Jung Han Choi Jung Han Kim Zhengri Li Han Jin Oh Kyu Youn Ahn Kyung Chul Yoon
- 간행물 정보
- 『The Korean Journal of Ophthalmology』Vol.29 No.2, 131~137쪽, 전체 7쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2015.04.30
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국문 초록
영문 초록
Purpose: To investigate the therapeutic effects of mineral oil (MO) and hyaluronic acid (HA) mixture eye drops on the tear film and ocular surface in a mouse model of experimental dry eye (EDE).
Methods: Eye drops consisting of 0.1% HA alone or mixed with 0.1%, 0.5%, or 5.0% MO were applied to desiccating
stress-induced murine dry eyes. Tear volume, corneal irregularity score, tear film break-up time (TBUT), and corneal fluorescein staining scores were measured at 5 and 10 days after treatment. Ten days after treatment, goblet cells in the conjunctiva were counted after Periodic acid-Schiff staining.
Results: There was no significant difference in the tear volume between desiccating stress-induced groups.
The corneal irregularity score was lower in the 0.5% MO group compared with the EDE and HA groups. The 0.5% and 5.0% MO groups showed a significant improvement in TBUT compared with the EDE group. Mice treated with 0.1% and 0.5% MO mixture eye drops showed a significant improvement in fluorescein staining scores compared with the EDE group and the HA group. The conjunctival goblet cell count was higher in the 0.5% MO group compared with the EDE group and HA group.
Conclusions: The MO and HA mixture eye drops had a beneficial effect on the tear films and ocular surface of
murine dry eye. The application of 0.5% MO and 0.1% HA mixture eye drops could improve corneal irregularity,
the corneal fluorescein staining score, and conjunctival goblet cell count compared with 0.1% HA eye drops in the treatment of EDE.
목차
Materials and Methods
Results
Discussion
Conflict of Interest
Acknowledgements
References
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