학술논문
Deep Anterior Lamellar Keratoplasty Using Irradiated Acellular Cornea with Amniotic Membrane Transplantation for Intractable Ocular Surface Diseases
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- 영문명
- 발행기관
- 대한안과학회
- 저자명
- Sung Wook Wee Sang Uk Choi Jae Chan Kim
- 간행물 정보
- 『The Korean Journal of Ophthalmology』Vol.29 No.2, 79~85쪽, 전체 7쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2015.04.30
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국문 초록
영문 초록
Purpose: To report the clinical outcomes of deep anterior lamellar keratoplasty (DALK) when sterile gamma-irradiated
acellular corneal tissues (VisionGraft) are used in combination with amniotic membrane transplantation
(AMT) for intractable ocular surface diseases.
Methods: The medical records of fifteen patients who had DALK with AMT were retrospectively reviewed. Indications
for surgery included ocular burn, bacterial keratitis, herpes simplex virus keratitis, corneal opacity with
Stevens-Johnson syndrome, Mooren’s ulcer, idiopathic myxoid degeneration of corneal stroma, and recurrent
band keratopathy. DALK was performed using partial-thickness acellular corneal tissue and a temporary amniotic
membrane patch was added at the end of the operation.
Results: All cases that underwent DALK with AMT became epithelialized within 2 postoperative weeks. Twelve
patients showed favorable outcomes without graft rejection, corneal opacification, or neovascularization. The
other three grafts developed corneal opacification and neovascularization, and required additional penetrating
keratoplasty (PK). Unlike the results of previous PKs, there were no graft rejections and the graft clarity was
well-maintained in these three cases for at least 8 months after PK.
Conclusions: DALK using sterile acellular corneal tissues in combination with AMT may be a good therapeutic
strategy for treating intractable ocular surface diseases because of lowered immune rejection, fibroblast activation,
and facilitation of epithelialization. Furthermore, DALK can help stabilize the ocular surface, prolong
graft survival, and may allow better outcomes when combined with subsequent PK.
목차
Materials and Methods
Results
Discussion
Conflict of Interest
References
키워드
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