환경 바이오모니터링에서의 혈중 중금속 분석 숙련도 시험을 위한 표준물질 제조 및 적용성 평가

• 영문명: Development and Validation of Reference Material for Proficiency Testing of Blood Heavy Metals in Environmental Biomonitoring
• 발행기관: 한국환경보건학회
• 저자명: 임호섭(Hosub Im) 양민호(Minho Yang) 오세림(Selim Oh) 김소영(Soyoung Kim) 정호준(Hojun Jung) 조용민(Yong Min Cho) 이정섭(Jung Sub Lee) 김현정(Hyun Jeong Kim) 이채관(Chae Kwan Lee) 문찬석(Chan-Seok Moon) 이종화(Jong-Wha Lee)
• 간행물 정보: 『1. 한국환경보건학회지』제42권 제6호, 450~464쪽, 전체 15쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2016.12.30

영문 초록

Objectives: This study developed and validated reference materials (RMs) to analyze metal compounds in blood. Methods: We referred to KoNEHS (Korea National Environmental Health Survey) to estimate concentrations of blood metals (cadmium, Cd; lead, Pb; mercury, Hg) and applied analytical methods (inductively coupled plasma – mass spectroscopy, ICP-MS, for Cd and Pb; graphite furnace – atomic absorption spectrometry, GFAAS, for Cd and Pb; and direct mercury analyzer, DMA, for Hg). Homogeneity and stability tests were carried out. In addition, certified values and uncertainties of RMs were calculated through internal and external experiments. All RMs were developed and assessed in various forms according to element, analytical method, and two types of concentration levels high concentration for occupational exposure and low concentration for environmental exposure. Results: All samples showed acceptable homogeneity, except for low concentration of Cd in the GF-AAS method. Short- and long-term stabilities were satisfied by ANOVA testing. In the inter-laboratory comparison, robust medians were lower than the certified values of all RMs (robust median/reference value; 1.301/1.327 μg/L for Cd, ICP-MS, low concentration; 3.152/3.388 μg/L for Cd, ICP-MS, high concentration; 1.219/1.301 μg/L for Cd, GF-AAS, low concentration; 3.074/3.321 μg/L for Cd, GF-AAS, high concentration; 14.473/14.516 μg/L for Pb, ICP-MS, low concentration; 50.069/50.114 μg/L for Pb, ICP-MS, high concentration; 12.881/14.147 μg/L for Pb, GF-AAS, low concentration; 47.015/47.591 μg/L for Pb, GF-AAS, high concentration; 4.059/4.218 μg/L for Hg, DMA, low concentration; 11.474/11.181 μg/L for Hg, DMA, high concentration). Conclusion: This study demonstrates procedures for developing and validating RMs for biomonitoring in the field of the environmental health.

목차

I. Introduction

II. Materials and Methods

III. Results

IV. Discussion

V. Conclusion

키워드

Biomonitoring blood cadmium blood lead blood mercury reference materials