커피생콩 추출물에 의한 안면부 통증조절 효과

• 영문명: Regulation effects of orofacial pain by green coffee bean extracts in rats
• 발행기관: 한국구강보건과학회
• 저자명: 이민경(Min-Kyung Lee) 김희진(Hee-Jin Kim) 박민경(Min-Kyoung Park)
• 간행물 정보: 『한국구강보건과학회지』제6권 제2호, 53~58쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2018.09.30

영문 초록

Green coffee bean (GCB) is a raw coffee bean that has not yet been roasted. Green coffee bean is the unroasted or immature robust coffee bean. It is mostly composed of Chlorogenic Acids (CGA), caffeine, trigonelline, and the diterpenes cafestol and kahweol. Chlorogenic Acids (CGA) have the anti-cancer effect of restraining free oxygen radicals. Even though experiments using Green Coffee Bean Exract (GCBE) have been done in various fields, experiments with regard to orofacial pain have been few. The aim of this study is to investigate whether administration of GCBE may be beneficial in pain modulation in inflammatory orofacial pain. We investigated by using GCBE in the development and modulation of orofacial pain in rats. Male, 7- to 8-week-old, Sprague-Dawley rats weighing 240-280g were used in this study. Experiments were carried out using a subcutaneous (SC) pain model caused by the injection of 5% formalin into the right vibrissa pad (SC, 50 μl). The amount of scratching or rubbing to the injection site was recorded for 9 consecutive 5-minute intervals following in-jection of formalin. The experimental subjects were separated into 5 groups (n=4); Naive, for-malin(5%), formalin after distilled water (vehicle), formalin after GCBE (p.o.,concentrations of 30,60mg/mL). The number of behavioral reactions of scratching the facial region proximal to the injection site was recorded for 9 consecutive 5-minute intervals following injection of the formalin. As a result, we found that oral administration of GCBE (p.o., concentrations of 30, 60 mg/mL) has an effect of relieving the formalin-induced orofacial pain. In particular, high con-centrations (60 mg/mL) of GCBE substantially decrease the nociceptive behavior. These results mean that GCBE may affect the occurrence of orofacial pain and modulation. Therefore, Green coffee bean extract may be a potential therapeutic treatment for orofacial pain.

목차

Ⅰ. 서 론

Ⅱ. 연구 대상 및 방법

Ⅲ. 결과

Ⅳ. 고찰 및 결론

키워드

Green coffee bean Orofacial pain Formalin