고지방 식이로 유도된 C57BL/6 마우스에서 단삼사물탕의 항비만효과에 관한 연구

• 영문명: Anti-obesity Effect and Action Mechanism of Dansam-Samultang in C57BL/6 Obese Mice Fed High Fat Diet
• 발행기관: 한국인체미용예술학회
• 저자명: 이성은(Seong-Eun Lee)
• 간행물 정보: 『한국인체미용예술학회지』한국인체미용예술학회지 제19권 제2호, 111~123쪽, 전체 13쪽
• 주제분류: 예술체육 > 예술일반
• 파일형태: PDF
• 발행일자: 2018.06.30

영문 초록

This study investigated the anti-obesity mechanism and effects of Dansam (Salvia miltiorrhiza)-Samultang(mixed herbal medicine). For this, C57BL/6 was divided into five groups: a normal group (N) with regular diet, a control group (C) with high-fat diet (HFD), an ‘HFD+0.5% catechin’ supplemented positive control group (PC), a ‘HFD+0.5% Dansam-Samultang’ supplemented experimental group (E1), and a ‘HFD+0.1% Dansam-Samultang’ supplemented experimental group (E2). Compared to the C, the E1 and E2 revealed significant improvement in body weight changes, hematological/ serum-biochemical data and total antioxidant status (TAS) in the adipose tissues of epididymis and the liver. From the perspective of molecular biology, Adiponectin, AMPK and PPARα revealed significant increases in the experimental groups in comparison to the control group. In contrast, TNFα, GPDH and PPARγ showed statistically significant decreases in the experimental groups, compared to the control group. These results found the mechanism and anti-obesity effects of Dansam-Samultang through its antioxidant and anti-inflammatory activities. Therefore, it appears that Dansam-Samultang would be useful as a natural substance for the prevention and treatment of obesity and metabolic syndrome caused by oxidative stress.

목차

Ⅰ. 서론

Ⅱ. 이론적 배경

Ⅲ. 재료 및 방법

Ⅳ. 결과 및 고찰

Ⅴ. 요약

키워드

anti-obesity(항비만) Dansam-Samultang(단삼사물탕) antiinflammatory(항염증) anti-oxidative(항산화) C57BL/6