α-Tocopherol 급여 흰쥐의 paraquat 중독에 관한 연구

• 영문명: A study on paraquat poisoning of α-Tocopherol supplemented rats
• 발행기관: 한국예방수의학회
• 저자명: 조종후(Jong Ho Cho) 신광순(Kwan Soon Shin)
• 간행물 정보: 『Korean Journal of Veterinary Public Health』Vol.9, No.2, 1~6쪽, 전체 6쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 1985.11.30

영문 초록

Percent hemolysis of erythrocyte, plasma trypsin inhibitor capacity and glutathione peroxidase activity were measured in erythrocytes and plasma after 100 mg/kg po(LD 50) dose of paraquat to Wistar rats presupplemented for 4 weeks at dietary levels of 0,10,50,100, and 1,000ppm, and after access to diets containing various levels of α-tocopherol and 300 ppm paraquat water of libitum for 4 weeks. The results obtained were summarized as follows: 1. Presupplement of a-tocopherol at a concentration of less than about 10 mg/kg for 4 weeks significantly increased percent hemolysis of erythrocytes by dialuric acid. 2. Percent hemolysis of erythrocytes after a single toxic paraquat doses to rats presupplemented with various concentrations of α-tocopherol was not significantly altered from control values. 3. Chronic administration of 300 ppm paraquat water to rats presupplemented with α-tocopherol significantly increased percent hemolysis. Especially rats presupplemented with α-tocopherol of less concentrations than 10 mg/kg show-ed a remarkable elevation of percent hemolysis. 4. Plasma trypsin inhibitor capacity was significantly increased in almost of all groups of rats after paraquat treat-ment. But plasma trypsin inhibitor capacity after chronic doses of paraquat was significantly greater than that seen in a single toxic dose of paraquat, showing the protective effect of α-tocopherol against acute paraquat poisoning especially when α-tocopherol at a concentration of 1,000 mg/kg was supplemented to rats. 5. Plasma and erythrocyt glutathione peroxidas activities were not altered by chronic paraquat treatment.

목차

Abstract

서론

실험재료 및 방법

실험결과

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