제2형 당뇨병성 말초신경병증을 치료하기 위한 항산화요법에 대한 고찰

• 영문명: Antioxidant therapy of type 2 diabetic peripheral neuropathy
• 발행기관: 대한약학회
• 저자명: 박현배(Hyun Bae Park) 김지성(Ji Sung Kim) 한상배(Sang-Bae Han)
• 간행물 정보: 『약학회지』제62권 제2호(2018년), 126~134쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2018.03.30

국문 초록

Diabetic peripheral neuropathy (DPN) is a nerve damage caused by chronically high blood glucose and dia-betes. It leads to loss of sensation and sometimes pain in feet, legs and hands. More than 50% of type 2 diabetic patients will develop this complication. To date, the pathogenesis of DPN remains unclear. However, hyperglycemia, metabolic imbal-ance, and oxidative stress appear in the neurons of DPN patients. In addition, oxidative stress results in the change of poly-ADP-ribose polymerase, advanced glycation end products, polyol, protein kinase C, and hexosamine and causes endothelial cell damage and vascular dysfunction, consequently causing peripheral nerve ischemia and hypoxia. According to the oxi-dative stress and related pathways of DPN, some drugs are used in clinical treatment, such as taurine, acetyl-L-carnitine, aldose reductase inhibitors (epalrestat, ranirestat), α-lipoic acid (ALA), protein kinase C inhibitor (ruboxistaurin), inhibitor of poly ADPribose polymerase (nicotinamide), angiotensin-converting enzyme inhibitor (trandolapril), and advanced gly-cation end product inhibitors (aspirin, benfotiamine). However, no drugs can completely cure it. In this review, we sum-marize the pathogenesis of DPN and suggest that amifostine, which is clinically used as an antioxidant, might be used for the treatment of DPN.

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키워드

Diabetic peripheral neuropathy Type 2 diabetes Oxidative stress Antioxidant therapy