불발효차 우전, 세작, 중작, 대작의 HCT116 세포사멸 효능

• 영문명: Comparison of Apoptosis of Non-fermented Teas in HCT116 Human Colon Cancer Cells
• 발행기관: 한국차학회
• 저자명: 권태은(Tae Eun Guon) 정하숙(Ha Sook Chung)
• 간행물 정보: 『한국차학회지』제24권 제1호, 60~65쪽, 전체 6쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2018.03.30

영문 초록

In this present study, we investigated the anticancer activities of non-fermented teas (Woojeon, Sejak, Jungjak and Daejak) in HCT116 human colon cancer cells. The antioxidant activities of Woojeon, Sejak, Jungjak and Daejak at 0.1 mg/mL in terms of their DPPH free radical scavenging activities were found to be 91.2, 91.6, 92.7 and 94.4%, respectively. The treatment of HCT116 human colon cancer cells with 0.6 mg/mL of Woojeon, Sejak, Jungjak and Daejak resulted in the characteristic sequence of apoptosis and morphological changes. The cell viability was also decreased upon the addition of Woojeon, Sejak, Jungjak and Daejak, and the main catechins, (-)-epicatechingallate, (-)-epigallocatechingallate and (-)-epigallocatechin, to HCT116 human colon cancer cells. Moreover, the Bax and Bcl-2 expression levels were increased, resulting in the activation of caspase-9, caspase-3 and cleaved poly-ADP-ribose polymerase; these observations are hallmarks of apoptotic events.

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키워드

non-fermented tea anti-proliferative apoptosis HCT116 cells catechins