차씨오일의 항산화 활성 및 뇌 해마유래 HT22 세포에서의 산화적 스트레스에 대한 보호효과

• 영문명: Antioxidant Activity and Protective Effect against Oxidative Stress on Hippocampal HT22 Cells of Tea Seed Oil
• 발행기관: 한국차학회
• 저자명: 김종민(Jong Min Kim) 박선경(Seon Kyeong Park) 강진용(Jin Yong Kang) 배성경(Seong-kyeong Bae) 정가희(Ga-Hee Jeong) 조경환(Kyoung Hwan Cho) 김종철(Jong Cheol Kim) 김재중(Jae Joong Kim) 허호진(Ho Jin Heo )
• 간행물 정보: 『한국차학회지』제24권 제1호, 53~59쪽, 전체 7쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2018.03.30

영문 초록

The antioxidant activities and hippocampal neuroprotective effects of tea (Camellia sinensis) seed oil against H 2 O 2 -induced oxidative stress were investigated to confirm its physiological effects. The antioxidant effects of tea seed oil were evaluated by measuring its 1,1-diphenyl-2-picrylhydrazyl, 2,2 -azino-bis (3-ethyl benzothiazoline-6-sulfonic acid) radical scavenging activities and malondialdehyde inhibitory effect. Tea seed oil was found to have significant antioxidant activity and inhibitory effect of lipid peroxidation. To confirm the ameliorating effect of the cholinergic system, the inhibitory effect of acetylcholinesterase (AChE) derived from PC12 was investigated. Tea seed oil was found to inhibit the AChE activity. Also, the protective effects of hippocampal neuronal cells against H 2 O 2 -induced neuronal cytotoxicity were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and 2 ,7 -dichlor-ofluorescein diacetate in HT22 cells. Tea seed oil was found to significantly increase the cell viability and reactive oxygen species scavenging activity.

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tea seed oil antioxidant effect acetylcholinesterase neuronal protection HT22 cell